GENE PANELS

STHT - OTHER SOLID TUMORS

DETAILS

 
Version :
Status :
Size :
Website :
3.1
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109 genes
Extra info :
Method :

Capture based panel, using the Roche KAPA HyperPlus kit and KAPA HyperChoice probes

CERTIFICATES

 
141-MED (UZ Brussel)
141-MED (UZ Brussel)

INSTRUMENTS

 
Illumina NovaSeq 6000
Illumina NovaSeq 6000

Our highest capacity short read sequencer. This device can generate reads up to 250 bp in length (on the SP flowcell) and generate up to 10B reads per flowcell (S4).

DOWNLOADS

 
Flyer2 GW testing white borders_edited.j
Genelist STHT other solid tumors

3.1

Flyer2 GW testing white borders_edited.j
STHT subpanels overview

3.1

CONTACT

 
pas14klein.jpg

Secretariaat Medische Genetica

+32 (0)2 477 64 79 (sec)

UZ Brussel

Centrum Medische Genetica

Laarbeeklaan 101

1090 Brussels

pas14klein.jpg

Freya Vaeyens

+32 (0)2 477 64 79 (sec)

UZ Brussel

Centrum Medische Genetica

Laarbeeklaan 101

1090 Brussels

SAMPLE TYPES

 

We aim to keep te list with sample types updated. However, if you believe we offer this gene panel on other sample types, of if you have a very specific sample type you'd like to evaluate : please contact the corresponding persons for either diagnostic or research purposes.

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Tissue
Recipient
Quantity
Transport
Purpose / Extract
Blood
EDTA tube
10 ml (min. 3 ml)
Room temperature
DNA
DNA from various tissues
Microtube*
See test details/specifications
Room temperature
DNA
DNA from various tissues
Microtube* or 96 well plate
See test details/specifications
Room temperature
DNA
FFPE block of various tissues
Paraffin block (in cassette)
Representative block ; Tumor load preferentially >10% ; To be processed by our pathology department (microtome section needed)
Room temperature
DNA
FFPE section of various tissues
Microtube*
Min. 1x 10 µm section (up to 2 mm³ tissue) ; Tumor load preferentially >10%
Room temperature
DNA
Tissue of various origins
Cryovial containing stabilizer (eg. AllProtect) or tissue homogenized on lysis buffer
Application/tissue specific (contact us)
Dry ice
DNA

* Microtube can be  a either a cryovial or eppendorf tube (0,5 ; 1,5 or 2 ml). Please consider the quality of the tube used (nuclease free ; free of RNA/DNA ; sterile ; LoBind) according to application needed.  

DELIVERABLES

 

Which data files can be retrieved from us for this specific gene panel?

Deliverable
Description
Research or diagnostic
Called variants - vcf file
Text file containing all detected variants as compared to the relevant reference genome
Diagnostic / RUO
Clinical report
Diagnostic report generated by Clinical Geneticist/ Pathologist
Diagnostic
Raw data - bam file
Binary data file containing the aligned reads
RUO (on request)
Raw data - fastq file
Data file containing the raw (unaligned) reads
RUO (on request)
Run folder
The complete run folder can be transferred if it concerns a run reservation (private run)
RUO (on request)
 

GENELIST

ACD
AKT1
AKT3
ALK
ANKRD26
ANTXR1
ANTXR2
APC
AR
ARAF
ARID1A
ATM
ATRX
AXIN1
BAP1
BARD1
BMPR1A
BRAF
BRCA1
BRCA2
CASP8
CDH1
CDK12
CDKN2A
CHEK1
CHEK2
COL2A1
CTNNB1
CUL4B
CYLD
CYSLTR2
DAXX
DCC
DDR1
DELEC1 (DEC1)
DICER1
DLC1
DMD
DNMT3A
DPH3
DPYD
EED
EGFR
EGLN1
EGLN2
ENG
EPAS1 (HIF2A)
EPCAM
ERBB2
ERBB3
ERBB4
EXT1
EXT2
FAT1
FAU
FBXW7
FGFR1
FGFR2
FGFR3
FH
FLCN
FLT4
FOXO1
GAB2
GLMN
GNA11
GNAQ
GNAS
HRAS
IDH1
IDH2
IL7R
JAK2
JAK3
KDR
KEAP1
KIF1B
KIT
KMT2D (MLL2)
KRAS
LATS1
LATS2
LEMD3
LSAMP
LYST
MAP2K1
MAP2K2
MAP3K8
MAX
MC1R
MDH2
MEF2B
MEN1
MET
MLH1
MSH2
MSH6
MTOR
MUTYH
MYB
MYOD1
NF1
NF2
NOTCH1
NRAS
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PHOX2B
PIK3CA
PIK3R1
PLCB4
PMS1 (MLH2)
PMS2 (MLH4)
POLD1
POLE
POT1
PPM1D
PPP2R2A
PPP6C
PRDM1
PRF1
PRKAR1A
PRKD2
PTCH1
PTEN
PTPN11
PTPRD
RAD51B
RAD54L
RAF1 (CRAF)
RB1
RET (MEN2)
RICTOR
ROBO1
ROBO2
ROS1
SDHA
SDHAF2
SDHB
SDHC
SDHD
SLC25A11
SLC29A3
SMAD4 (MADH4)
SMARCA4
SMARCB1
SMO
SPEN
STARD13
STK11
SUZ12
TEK
TENT5C (FAM46C)
TERF2IP
TERT
TMEM127
TP53
TPMT
TSC1
TSC2
UGT1A1
USP13
VHL
WAS (XLN/XLT)
WWOX
YEATS2