
GENE PANELS
LYMFOID MALIGNANCIES: IGH, IGK AND TCR BETA/GAMMA/DELTA REARRANGEMENTS

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Version :
1
Status :

Size :
5 genes
Start date :
Website :
Extra info :
Field of application
Diagnosis chronic lymphoid malignancies i.e. multiple myeloma, B-NHL, T-NHL… (RIZIV/INAMI reimbursement code: 588475-588486)
Diagnosis acute lymphoid malignancies i.e. ALL (RIZIV/INAMI reimbursement code: 588490-588501)
Follow-up chronic lymphoid malignancies i.e. multiple myeloma, B-NHL, T-NHL… (RIZIV/INAMI reimbursement codes: 588571-588582)
Follow-up acute lymphoid malignancies i.e. ALL (RIZIV/INAMI reimbursement code: 588571-588582)
Analysis: uitvoerfrequentie 1x/week. TAT maximaal 3 weken
Diagnostic samples:
LymphoTrack kits: LymphoTrack® Dx Software - MiSeq® - CE-IVD (Invivoscribe, 95000009)
EuroClonality protocol: Vidjil platform – RUO - (Duez M, Giraud M, Herbert R, Rocher T, Salson M, Thonier F. Vidjil: A Web Platform for Analysis of High-Throughput Repertoire Sequencing. PLoS One. 2016 Nov 11;11(11):e0166126. doi: 10.1371/journal.pone.0166126. Erratum in: PLoS One. 2017 Feb 9;12 (2):e0172249. PMID: 27835690; PMCID: PMC5106020.)
Follow-up samples
LymphoTrack® Dx Software - MiSeq® - CE-IVD (Invivoscribe, 95000009) in combination with the tracking of gBlocks (calibrators) – BELAC accreditated – (Van der Straeten J, De Brouwer W, Kabongo E, Dresse MF, Fostier K, Schots R, Van Riet I, Bakkus M. Validation of a PCR-Based Next-Generation Sequencing Approach for the Detection and Quantification of Minimal Residual Disease in Acute Lymphoblastic Leukemia and Multiple Myeloma Using gBlocks as Calibrators. J Mol Diagn. 2021 May;23(5):599-611. doi: 10.1016/j.jmoldx.2021.01.009. Epub 2021 Feb 4. PMID: 33549860.)
Sample types
We aim to keep the list with sample types updated. However, if you believe we offer this gene panel on other sample types, or if you have a very specific sample type you'd like to evaluate : please contact the corresponding persons for either diagnostic or research purposes.
* Microtube can be a either a cryovial or eppendorf tube (0,5 ; 1,5 or 2 ml). Please consider the quality of the tube used (nuclease free ; free of RNA/DNA ; sterile ; LoBind) according to application needed.

Blood > DNA
EDTA tube
10 ml (min. 3 ml)
Room temperature

DNA from various tissues > DNA
Microtube* or 96 well plate
See test details/specifications
Room temperature
Extra requirements
Absorbance ratio A260/A230 - Minimum
DNA from various tissues
Minimum: 1,5
Lower values are indicative for indicative for EDTA, carbohydrate, chaotropic salts (and also protein) contamination
Absorbance ratio A260/A280 - Minimum
DNA from various tissues
Minimum: 1,5
Lower values are indicative for indicative for protein, phenol or other aromatic compound contamination

Costs
For Diagnostic testing
When requested through your General Practitioner / Clinical Geneticist / Pathologist / Hematologist, costs will be covered through your health insurance. The costs involved will be those for your consultation and/or 'remgeld'.
For Research testing
Below, you can find indicative prices (excl. VAT) for all potential options you'd require to accomplish your project. If you are interested, please contact us to receive a tailored quotation.
Update pending
Our prices are being updated. More info soon.


Documents & certificates

141-MED (UZ Brussel)
