Gene Panel Sequencing
Via Gene Panel sequencing, it is possible to reduce the genomic information to a selected set of genes. In diagnostic gene panels, the selected set of genes are known to be involved in a specific pathology.
The capturing-based Gene Panel procedure is very similar to the Whole Exome Sequencing setup and we would like to refer to this section for more information.
Multiplex PCR based technologies are an alternative to the capturing based technologies
See capturing-based Gene Panel procedure in section Whole Exome Sequencing
List of currently available gene panels
The following tests are currently available through the BRIGHTcore, UZ Brussel and Hôpital Erasme laboratory services :
Dependent on the panel size and the requested average coverage, the most suitable platform will be selected.
Our routine Gene Panel procedure uses the following kits :
KAPA Hyper prep
Roche SeqCap EZ custom panels
Integrated DNA Technologies (IDT) xGen® Lockdown® Probes
Illumina TruSeq Amplicon